Gut-Brain Glucose Signaling in Energy Homeostasis

Publication date: 6 June 2017
Source:Cell Metabolism, Volume 25, Issue 6
Author(s): Maud Soty, Amandine Gautier-Stein, Fabienne Rajas, Gilles Mithieux
Intestinal gluconeogenesis is a recently identified function influencing energy homeostasis. Intestinal gluconeogenesis induced by specific nutrients releases glucose, which is sensed by the nervous system surrounding the portal vein. This initiates a signal positively influencing parameters involved in glucose control and energy management controlled by the brain. This knowledge has extended our vision of the gut-brain axis, classically ascribed to gastrointestinal hormones. Our work raises several questions relating to the conditions under which intestinal gluconeogenesis proceeds and may provide its metabolic benefits. It also leads to questions on the advantage conferred by its conservation through a process of natural selection.

Teaser

Soty et al. discuss how intestinal gluconeogenesis induced by specific nutrients initiates neural sensing of glucose in the portal vein and a central signal positively influencing parameters involved in glucose control and energy management. This knowledge has extended our vision of the gut-brain axis, classically ascribed to gastrointestinal hormones.


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