Type I Interferons Interfere with Liver Glucose Metabolism

Publication date: 6 June 2017
Source:Cell Metabolism, Volume 25, Issue 6
Author(s): Güneş Parlakgul, Gökhan S. Hotamisligil
The specific immunological components linking metabolic stresses to liver inflammation and systemic metabolic pathologies in obesity are not entirely known. A recent study (Ghazarian et al., 2017) reveals that obesity-induced type I interferon signaling drives the accumulation and activation of intrahepatic CD8⁺ T cells, leading to systemic metabolic deterioration.

Teaser

The specific immunological components linking metabolic stresses to liver inflammation and systemic metabolic pathologies in obesity are not entirely known. A recent study (Ghazarian et al., 2017) reveals that obesity-induced type I interferon signaling drives the accumulation and activation of intrahepatic CD8⁺ T cells, leading to systemic metabolic deterioration.


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