Long noncoding RNA linc00462 promotes hepatocellular carcinoma progression

Publication date: September 2017
Source:Biomedicine & Pharmacotherapy, Volume 93
Author(s): JianDe Gong, XuFei Qi, Yi Zhang, YingCong Yu, XiZhou Lin, HongLiang Li, YiRen Hu
BackgroundHepatocellular carcinoma (HCC) represents one of the most common malignancies worldwide. In two pubic long noncoding RNA (lncRNA) profiling studies of HCC, linc00462 was consistently upregulated. We analyzed the clinical significance and biological role of linc00462 in HCC.MethodsWe performed quantitative real-time PCR analysis to determine the levels of linc00462 in HCC tissues from 49 patients. Functional analysis was performed in cell lines and in an animal model to support clinical findings.ResultsOur data showed that linc00462 was significantly upregulated in HCC tissues compared with matched normal tissues. The knockdown of linc00462 in HCC cells resulted in a much less aggressive oncogenic phenotype, and linc00462 downregulation contribute to the inactivation of the PI3K/AKT signaling pathway.Conclusionslinc00462 may be a potential therapeutic target in HCC.



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