Obese Asthmatics Have Decreased Surfactant Protein-A Levels: Mechanisms and Implications

SP-A secretion by epithelial cells is attenuated by TNF-α, a cytokine increased in obese asthmatics. SP-A plays an important role in resolving tissue eosinophilia, therefore obese asthmatics may have prolonged tissue eosinophilia due to significantly decreased SP-A levels.

http://ift.tt/2sqRiAW