The aim of this study was to evaluate efficacy and safety of amfepramone, fenproporex and mazindol as a monotherapy for the treatment of obese or overweight patients. A systematic review of primary studies was conducted, followed by a direct meta-analysis (random effect) and mixed treatment comparison. Medline and other databases were searched. Heterogeneity was explored through I2 associated with a p-value. Of 739 identified publications, 25 were included in the meta-analysis. The global evaluation of Cochrane resulted in 19 studies with a high level of bias and six with unclear risk. Due to the lack of information in primary studies, direct meta-analyses were conducted only for amfepramone and mazindol. Compared to placebo, amfepramone resulted in higher weight loss in the short-term (<180 days; mean difference (MD) -1.281 kg; p<0.05; I2: 0.0%; p=0.379) and long-term (≥180 days; MD -6.518 kg; p<0.05; I2: 0.0%; p=0.719). Only studies with long-term follow up reported efficacy in terms of abdominal circumference and 5-10% weight reduction. These results corroborated the finding that the efficacy of amfepramone is greater than that of placebo. Treatment with mazindol showed greater short-term weight loss than that with placebo (MD -1.721 kg; p<0.05; I2: 0.9%; p=0.388). However, metabolic outcomes were poorly described, preventing a meta-analysis. A mixed treatment comparison corroborated the direct meta-analysis. Considering the high level of risk of bias and the absence of important published outcomes for anti-obesity therapy assessments, this study found that the evaluated drugs showed poor evidence of efficacy in the treatment of overweight and obese patients. Robust safety data were not identified to suggest changes in their regulatory status.
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Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Πέμπτη 1 Ιουνίου 2017
Systematic review and meta-analysis of the efficacy and safety of amfepramone and mazindol as a monotherapy for the treatment of obese or overweight patients
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- Activated Plasmacytoid Dendritic Cells regulate Ty...
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- Assessment of thunderstorm-induced asthma using Go...
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- Surrogate Outcome Measures for Corneal Neurotizati...
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- Coexistence of Lymphoepithelial Carcinoma of the P...
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- Nasolabial Growth in Individuals With Unilateral C...
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- Nasal Root Deviation in Unicoronal Craniosynostosi...
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- How to Achieve Facial Balance by Mandibular Contou...
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- The Superficial Musculoaponeurotic System Facelift...
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- Lateral Crural Tensioning for Refinement of the Na...
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- The Horizontal Neck Lift
- V-Y Advancement Flap for Defects of the Lid–Cheek ...
- The Difficult Neck in Facelifting
- Cheek and Chin Implants to Enhance Facelift Results
- V-Y Advancement Flap for Defects of the Lid–Cheek ...
- Cheek and Chin Implants to Enhance Facelift Results
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- Effects of Tumescent Solution on Fat Survival
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- Spectral and temporal properties of calls reveal d...
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