Inflammation in the assessment of salivary cytokines in oral squamous cell carcinoma diagnosis

During a literature search about the role of molecular markers in accurate diagnosis and prognosis of oral malignant lesions, we have encountered a valuable paper entitled "Oral squamous cell carcinoma detection by salivary biomarkers in a Serbian population", authored by Brinkmann O, Kastratovic DA, Dimitrijevic MV, Konstantinovic VS, Jelovac DB, Antic J, Nesic VS, Markovic SZ, Martinovic ZR, Akin D, Spielmann N, Zhou H, Wong DT, published in Oral Oncology 2011 January; 47(1): 51–55. In that study, the authors investigated six transcriptome (DUSP1, IL8, IL1β, OAZ1, SAT1, S100P) and three proteome (IL1β, IL8, M2BP) biomarkers on 18 early and 17 late stage OSCC patients and 51 healthy controls with quantitative PCR and ELISA.

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