Why are we still unable to accurately determine the malignant potential or the behavior of oral mucosal lesions?

We read with great interest an editorial by Guneri et al. [1] titled 'Why are we still unable to accurately determine the malignant potential or the behavior of oral mucosal lesions?' It is appropriately said that despite extensive advances in diagnostic research, there are still no biomarkers (clinical, biochemical or molecular) available in clinical practice that can truthfully determine the malignant potential or behavior of oral potentially malignant disorders (OPMDs). The oldest paper available in the PubMed in this regard was published in 1948 [2].

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