Stereoselective synthesis of 25S,26-dihydroxyvitamin D3

Publication date: Available online 18 July 2017
Source:The Journal of Steroid Biochemistry and Molecular Biology
Author(s): Rita Sigüeiro, Patricia González-Berdullas, Julian Loureiro, Antonio Mouriño, Miguel A. Maestro
A convergent approach to 25S,26-dihydroxyvitamin D3 (1) has been developed in our laboratories. The A-ring and the CD-fragment are constructed from ergocalciferol and Inhoffen-Lythgoe diol, respectively. The triene system is assembled by a Wittig-Horner coupling. With this convergent synthesis, a novel hydroxylated vitamin D metabolite in our laboratory is available for biological testing.



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