Apparent diffusion coefficient in the analysis of prostate cancer: determination of optimal b-value pair to differentiate normal from malignant tissue

Publication date: Available online 8 September 2017
Source:Clinical Imaging
Author(s): Nuno Adubeiro, Maria Luísa Nogueira, Rita G. Nunes, Hugo Alexandre Ferreira, Eduardo Ribeiro, José Maria Ferreira La Fuente
PurposeDetermining optimal b-value pair for differentiation between normal and prostate cancer (PCa) tissues.MethodsForty-three patients with diagnosis or PCa symptoms were included. Apparent diffusion coefficient (ADC) was estimated using minimum and maximum b-values of 0, 50, 100, 150, 200, 500s/mm2 and 500, 800, 1100, 1400, 1700 and 2000s/mm2, respectively. Diagnostic performances were evaluated when Area-under-the-curve (AUC)>95%.Results15 of the 35 b-values pair surpassed this AUC threshold. The pair (50, 2000s/mm2) provided the highest AUC (96%) with ADC cutoff 0.89×10–³mm²/s, sensitivity 95.5%, specificity 93.2% and accuracy 94.4%.ConclusionsThe best b-value pair was b=50, 2000s/mm2.



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