Abstract
Our modern lifestyle is characterized by easy access to nutrient dense foods combined with limited physical activity. A sedentary lifestyle is one of several factors that have contributed to the global obesity epidemic and also predisposes to chronic illnesses such as diabetes and cardiovascular disease. While many studies have focused on the benefits of exercise in peripheral tissues, the contributions of the central nervous system to these exercise-induced metabolic adaptations are relatively unknown. This review will highlight the role of the ventromedial hypothalamus (VMH) in regulating the metabolic response to exercise.
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