Publication date: December 2017
Source:Biomedicine & Pharmacotherapy, Volume 96
Author(s): Reyhaneh Naderi, Saeed Esmaeili-Mahani, Mehdi Abbasnejad
The phytohormone abscisic acid (ABA) exists in animal tissues particularly in the brain. However, the neurophysiological effects of ABA have not yet been fully determined. Signaling molecules such as PKC and PI3K have been implicated in anxiety-like behavior as well as learning and memory processes. Recently, it has been demonstrated that PKC and PI3K signaling pathways participate in some biological effects of ABA. This study was designed to evaluate the effects of central injection of ABA on spatial learning and memory and anxiety-like behavior and determine its possible signaling mechanisms. Spatial learning and memory and anxiety-like behaviors were determined using Morris water maze (MWM) and plus maze tests, respectively. ABA alone or in accompanied with selective inhibitors of PKC (chelerythrine) and PI3K (LY2940029) was injected bilaterally into the cerebral lateral ventricles. The results indicated that ABA (10μg/rat) significantly improved rats' performance in MWM which was blocked by PKC or PI3K inhibitors. In addition, ABA showed anti-anxiety effect in plus maze test, which was not observed in PKC or PI3K inhibitor-treated rats. Overall, the results indicated that ABA has positive effect on spatial learning and memory performance and elicits anti-anxiety effects which are performed, at least in part, through PI3K/PKC signaling pathway.
http://ift.tt/2xEzUeV
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Σάββατο 30 Σεπτεμβρίου 2017
Phosphatidylinositol-3-kinase and protein kinase C are involved in the pro-cognitive and anti-anxiety effects of phytohormone abscisic acid in rats
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- Optical molecular analysis using office flatbed ph...
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- Cost analysis of a speech pathology synchronous te...
- Comparison of outcomes with extensive segmental pe...
- Serum parathyroid hormone and alkaline phosphatase...
- Role of macrophage migration inhibitory factor in ...
- Phase I study of induction chemotherapy with afati...
- Modified technique for preservation of inferior al...
- “Airborne” suture tying technique: Simple steps to...
- 18F-Fluoromisonidazole positron emission tomograph...
- Justification of routine venous thromboembolism pr...
- Surrogate for oropharyngeal cancer HPV status in c...
- Therapeutic lateral neck dissection in well-differ...
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