Zn(II), Cd(II) and Hg(II) metal complexes of 2-aminonicotinaldehyde: Synthesis, crystal structure, biological evaluation and molecular docking study

Publication date: 1 January 2018
Source:Inorganica Chimica Acta, Volume 469
Author(s): Ramachary Mallela, Ramaiah Konakanchi, Ramu Guda, Nethaji Munirathinam, Durgaiah Gandamalla, Narsimha Reddy Yellu, Laxma Reddy Kotha
In this report, the ligand, 2-aminonicotinaldehyde (ANA) and its metal complexes [Zn(ANA)2Cl2], [Cd(ANA)2Cl2] and [Hg(ANA)2Cl2] have been synthesized and characterized by analytical and various spectroscopic (IR, Electronic, ¹H and ¹³C NMR) studies. The single crystal X-ray diffraction studies of ANA and [Zn(ANA)2Cl2] complex have been discussed. It was found that intra/intermolecular hydrogen bonding exists in both compounds and N-atom of pyridine ring of ANA coordinated to the metal ion in tetrahedral fashion. Metal chlorides, ANA and its complexes were subjected to biological screening, antioxidant, in vitro cytotoxicity and EGFR (Epidermal growth factor receptor) targeting molecular docking studies which indicated the synergistic effect of metal complexes on the biological activity than the free ligand and metal chlorides.

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