Reactions between methylglyoxal and its scavengers in-vivo appear to be catalyzed enzymatically

Publication date: Available online 9 October 2017
Source:Medical Hypotheses
Author(s): Benjamin Szwergold
Methylglyoxal (MGO) is an important contributor to the development of diabetic complications. In this paper I propose that MGO, not detoxified by the glyoxalase system, is removed from circulation by MGO-scavengers. Furthermore, since rates of reactions between MGO and its scavengers in-vitro are low, I propose that in-vivo these reactions are catalyzed enzymatically.



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