The Burgeoning World of Immunometabolites: Th17 Cells Take Center Stage

Publication date: 3 October 2017
Source:Cell Metabolism, Volume 26, Issue 4
Author(s): Glenn R. Bantug, Christoph Hess
Dysregulation of the Th17/Treg balance is a key driver of autoimmunity. A new study by Xu et al. (2017) has revealed that small-molecule inhibition of 2-hydroxyglutarate synthesis skews Th17 differentiation to the Treg lineage, which is protective against autoimmune inflammation.

Teaser

Dysregulation of the Th17/Treg balance is a key driver of autoimmunity. A new study by Xu et al. has revealed that small-molecule inhibition of 2-hydroxyglutarate synthesis skews Th17 differentiation to the Treg lineage, which is protective against autoimmune inflammation.


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