Publication date: Available online 10 October 2017
Source:Practical Radiation Oncology
Author(s): Hee Joon Bae, Omar Mian, Dhananjay Vaidya, Theodore L. DeWeese, Daniel Y. Song
IntroductionProstate hypertrophy, median lobe hypertrophy (MLH) and pubic arch interference (PAI) are relative contraindications to brachytherapy due to potential morbidity and technical considerations. GnRH analogues or non-steroidal anti-androgens are currently utilized to achieve prostatic downsizing prior to brachytherapy. However, such agents have been associated with effects on body habitus, metabolism, and quality of life. In contrast, 5-alpha reductase inhibitors (5-ARI) are far less frequently associated with these morbidities.Materials and MethodsPatients with large gland size, MLH or PAI were offered 5-ARI therapy. Repeat TRUS was performed at 3–4months, followed by brachytherapy if resolution achieved. If downsizing was inadequate, then patients were offered continuation of 5-ARI for additional 3months, or GnRH agonist or antiandrogen therapy, or other curative treatment.ResultsOf 59 patients with follow-up available, 42 (71%) were deemed to have adequate downsizing; 37 (63%) after 3–4months of 5-ARI, and 5 (8%) after 7–8months. Seventeen patients (29%) received other treatments due to inadequate effect. Median volume reduction was 20%.Of 41 patients undergoing brachytherapy, 4 (9.7%) required temporary catheterization due to obstruction. Median follow-up after implantation was 25months (1–64months). Median time for return to IPSS ≤5 of baseline score was 7months (IQR 6–13months). All but 1 patient who received brachytherapy remain biochemically controlled.Discussion5-ARI monotherapy is an alternative for downsizing in patients with hypertrophy or PAI, with over 70% achieving adequate downsizing without use of GnRH analogues or antiandrogens. Patients who received brachytherapy experienced typical rates of post-implant urinary morbidity.SummaryAndrogen suppression in the form of luteinizing-hormone releasing hormone analogues or anti-androgens are currently utilized prior to brachytherapy for patients who have prostate hypertrophy or pubic arch interference. However, these agents have undesirable side effect profiles and have been associated with increased risk of cardiac mortality. We describe our experience with utilizing 5-alpha-reductase inhibitors alone as an alternative for this indication.
http://ift.tt/2wNM3dH
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
►
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
▼
2017
(111579)
- ► Δεκεμβρίου (7718)
-
▼
Οκτωβρίου
(6996)
-
▼
Οκτ 11
(176)
- Microphthalmia with linear skin defects (MLS) synd...
- Linear IgA bullous dermatosis associated with amyo...
- Milia: a useful clinical marker of CYLD mutation c...
- Microphthalmia with linear skin defects (MLS) synd...
- Linear IgA bullous dermatosis associated with amyo...
- Milia: a useful clinical marker of CYLD mutation c...
- Scorpion bite-induced ischaemic stroke
- Oesophageal ischaemia: an uncommon cause of chest ...
- Posterior fossa progressive multifocal leukoenceph...
- Subclinical meningoventriculitis as a cause of obs...
- A unique case of nephrogenic systemic fibrosis fro...
- Allergic bronchopulmonary mycosis presenting as a ...
- Unusual case of prosthetic joint infection caused ...
- Cryptococcus neoformans osteomyelitis and intramus...
- Olfactory bulb agenesis with normal sexual hormones
- Hydatid cyst of the thigh: a challenging diagnosis
- Syncope from radiation-induced baroreceptor failure
- Live 'Baby dance among the red blood cells
- Erdheim-Chester disease: atypical presentation of ...
- Radioactive and stable cesium isotope distribution...
- Cancer Immunotherapy Trials Underutilize Immune Re...
- A Comprehensive Review of Sequencing and Combinati...
- Cost‐Effectiveness of Nivolumab in Recurrent Metas...
- Outcomes of a Specialized Interdisciplinary Approa...
- Prof. Gian Franco Bottazzo MD FRCP FRCPath (1946–2...
- Luciano Martini (1927–2017): a memoir
- Peritoneal pre-conditioning reduces macrophage mar...
- Synchronous HPV-Related Cancer of Bilateral Tonsil...
- Synchronous HPV-Related Cancer of Bilateral Tonsil...
- Management of Patients who Receive an Organ Transp...
- Rhesus Alloimunization Occurs After Rh Incompatibl...
- Venous Thromboembolism After Adult Lung Transplant...
- The Optimization of the Prevascularization Procedu...
- Interactive effects of PAHs with different rings a...
- In search of a comprehensible set of endpoints for...
- Prognostic significance of standardized uptake val...
- Prognostic significance of standardized uptake val...
- Fluoride containing bioactive glass composite for ...
- Structural and Ultrastructural Analyses of Bone Re...
- Effect of an alkaline environment on the engineeri...
- Continuous positive airway pressure treatment with...
- The effect of sleep duration and sleep quality on ...
- Assessment of intervention-related changes in non-...
- Prevalence of sleep-disordered breathing in Japane...
- Longitudinal associations between sleep and anxiet...
- Analysis and experimental evaluation of shunt acti...
- Long-term treatment with dopamine D3 receptor agon...
- Gender differences in sleep symptoms after repeat ...
- Photoreduction of Cr(VI) in water using BiVO 4 -Fe...
- The role of α1- and α2-adrenoceptor subtypes in th...
- Audiological findings in a de novo mutation of ANK...
- The addition of PRP to facial lipofilling: a doubl...
- The lateral thigh perforator (LTP) flap for autolo...
- Complications and Patient-Reported Outcomes after ...
- Outcomes After Phalloplasty: Do Transgender Patien...
- From Classical to Unusual: Report on 5 Cases of Tr...
- Tumour auto-contouring on 2d cine MRI for locally ...
- Interim 18F-FDG-PET/CT during chemo-radiotherapy i...
- Split-Overlapping Genioplasty: Surgical Technique,...
- A Research of Pyogenic Granuloma Genesis Factor Wi...
- Lolium perenne peptides for treatment of grass pol...
- Genome-wide association study and meta-analysis in...
- A systematic review of factors affecting vaccine u...
- Salmonella Enteritidis with double deletion in pho...
- Personality and demographic correlates of New Zeal...
- Parental perceptions of childhood seasonal influen...
- Evaluation of T and B memory cell responses elicit...
- Association of both consistency and strength of se...
- Investigating the candidacy of a capsular polysacc...
- Cost-effectiveness of a potential group B streptoc...
- Adjuvanting an inactivated influenza vaccine with ...
- Value of an in-depth analysis of unpublished data ...
- Trends in pneumococcal meningitis hospitalizations...
- CHRONOVAC VOYAGEUR: A study of the immune response...
- Nano-material as an excellent catalyst for reducin...
- Food stories: Unraveling the mechanisms underlying...
- EZH2 regulates dental pulp inflammation by direct ...
- A dual energy micro-CT methodology for visualizati...
- Different levels of visual perceptual skills are a...
- Cancer Drugs Dominate New FDA Watch List
- FTIR and GC-MS spectral datasets of wax from Pinus...
- Microarray analysis of subcutaneous adipose tissue...
- Survival Disparity Following Abdominal Aortic Aneu...
- Prevalence of pediatric alopecia areata among 572,...
- A meta-analysis of nevus-associated melanoma: Prev...
- Spectrum of orocutaneous disease associations
- Editorial Board
- CME examination
- Atypical features and systemic associations in ext...
- High prevalence of combination tanning among under...
- Spectrum of orocutaneous disease associations
- Assessment of dermatology clinic resources at safe...
- CME examination
- Intrathyroidal carotid artery and nonrecurring rig...
- Chimeric thoracoacromial artery perforator flap fo...
- Pathologic significance of a novel oncoprotein in ...
- Intrathyroidal carotid artery and nonrecurring rig...
- Familial clustering of oropharyngeal squamous cell...
- Diagnostik und operative Therapie des muskelinvasi...
- Light-emitting diode 585nm photomodulation inhibit...
-
▼
Οκτ 11
(176)
- ► Σεπτεμβρίου (7549)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
►
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
▼
2017
(111579)
- ► Δεκεμβρίου (7718)
-
▼
Οκτωβρίου
(6996)
-
▼
Οκτ 11
(176)
- Microphthalmia with linear skin defects (MLS) synd...
- Linear IgA bullous dermatosis associated with amyo...
- Milia: a useful clinical marker of CYLD mutation c...
- Microphthalmia with linear skin defects (MLS) synd...
- Linear IgA bullous dermatosis associated with amyo...
- Milia: a useful clinical marker of CYLD mutation c...
- Scorpion bite-induced ischaemic stroke
- Oesophageal ischaemia: an uncommon cause of chest ...
- Posterior fossa progressive multifocal leukoenceph...
- Subclinical meningoventriculitis as a cause of obs...
- A unique case of nephrogenic systemic fibrosis fro...
- Allergic bronchopulmonary mycosis presenting as a ...
- Unusual case of prosthetic joint infection caused ...
- Cryptococcus neoformans osteomyelitis and intramus...
- Olfactory bulb agenesis with normal sexual hormones
- Hydatid cyst of the thigh: a challenging diagnosis
- Syncope from radiation-induced baroreceptor failure
- Live 'Baby dance among the red blood cells
- Erdheim-Chester disease: atypical presentation of ...
- Radioactive and stable cesium isotope distribution...
- Cancer Immunotherapy Trials Underutilize Immune Re...
- A Comprehensive Review of Sequencing and Combinati...
- Cost‐Effectiveness of Nivolumab in Recurrent Metas...
- Outcomes of a Specialized Interdisciplinary Approa...
- Prof. Gian Franco Bottazzo MD FRCP FRCPath (1946–2...
- Luciano Martini (1927–2017): a memoir
- Peritoneal pre-conditioning reduces macrophage mar...
- Synchronous HPV-Related Cancer of Bilateral Tonsil...
- Synchronous HPV-Related Cancer of Bilateral Tonsil...
- Management of Patients who Receive an Organ Transp...
- Rhesus Alloimunization Occurs After Rh Incompatibl...
- Venous Thromboembolism After Adult Lung Transplant...
- The Optimization of the Prevascularization Procedu...
- Interactive effects of PAHs with different rings a...
- In search of a comprehensible set of endpoints for...
- Prognostic significance of standardized uptake val...
- Prognostic significance of standardized uptake val...
- Fluoride containing bioactive glass composite for ...
- Structural and Ultrastructural Analyses of Bone Re...
- Effect of an alkaline environment on the engineeri...
- Continuous positive airway pressure treatment with...
- The effect of sleep duration and sleep quality on ...
- Assessment of intervention-related changes in non-...
- Prevalence of sleep-disordered breathing in Japane...
- Longitudinal associations between sleep and anxiet...
- Analysis and experimental evaluation of shunt acti...
- Long-term treatment with dopamine D3 receptor agon...
- Gender differences in sleep symptoms after repeat ...
- Photoreduction of Cr(VI) in water using BiVO 4 -Fe...
- The role of α1- and α2-adrenoceptor subtypes in th...
- Audiological findings in a de novo mutation of ANK...
- The addition of PRP to facial lipofilling: a doubl...
- The lateral thigh perforator (LTP) flap for autolo...
- Complications and Patient-Reported Outcomes after ...
- Outcomes After Phalloplasty: Do Transgender Patien...
- From Classical to Unusual: Report on 5 Cases of Tr...
- Tumour auto-contouring on 2d cine MRI for locally ...
- Interim 18F-FDG-PET/CT during chemo-radiotherapy i...
- Split-Overlapping Genioplasty: Surgical Technique,...
- A Research of Pyogenic Granuloma Genesis Factor Wi...
- Lolium perenne peptides for treatment of grass pol...
- Genome-wide association study and meta-analysis in...
- A systematic review of factors affecting vaccine u...
- Salmonella Enteritidis with double deletion in pho...
- Personality and demographic correlates of New Zeal...
- Parental perceptions of childhood seasonal influen...
- Evaluation of T and B memory cell responses elicit...
- Association of both consistency and strength of se...
- Investigating the candidacy of a capsular polysacc...
- Cost-effectiveness of a potential group B streptoc...
- Adjuvanting an inactivated influenza vaccine with ...
- Value of an in-depth analysis of unpublished data ...
- Trends in pneumococcal meningitis hospitalizations...
- CHRONOVAC VOYAGEUR: A study of the immune response...
- Nano-material as an excellent catalyst for reducin...
- Food stories: Unraveling the mechanisms underlying...
- EZH2 regulates dental pulp inflammation by direct ...
- A dual energy micro-CT methodology for visualizati...
- Different levels of visual perceptual skills are a...
- Cancer Drugs Dominate New FDA Watch List
- FTIR and GC-MS spectral datasets of wax from Pinus...
- Microarray analysis of subcutaneous adipose tissue...
- Survival Disparity Following Abdominal Aortic Aneu...
- Prevalence of pediatric alopecia areata among 572,...
- A meta-analysis of nevus-associated melanoma: Prev...
- Spectrum of orocutaneous disease associations
- Editorial Board
- CME examination
- Atypical features and systemic associations in ext...
- High prevalence of combination tanning among under...
- Spectrum of orocutaneous disease associations
- Assessment of dermatology clinic resources at safe...
- CME examination
- Intrathyroidal carotid artery and nonrecurring rig...
- Chimeric thoracoacromial artery perforator flap fo...
- Pathologic significance of a novel oncoprotein in ...
- Intrathyroidal carotid artery and nonrecurring rig...
- Familial clustering of oropharyngeal squamous cell...
- Diagnostik und operative Therapie des muskelinvasi...
- Light-emitting diode 585nm photomodulation inhibit...
-
▼
Οκτ 11
(176)
- ► Σεπτεμβρίου (7549)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου