A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present

Publication date: 31 October 2017
Source:Cell Reports, Volume 21, Issue 5
Author(s): Jianpeng Sheng, Qi Chen, Irene Soncin, See Liang Ng, Klaus Karjalainen, Christiane Ruedl
Dendritic cells (DCs) and macrophages (Mϕs) share close developmental pathways and functional features, leading to blurring of the boundaries between these two cell lineages. However, a deeper understanding of DC and Mϕ ontogeny and more refined phenotypic and functional characterizations have helped to delineate pre-DC-derived conventional DCs (cDCs), including cDC1s and cDC2s, from monocyte-derived Mϕs. Here, we further refine DC/Mϕ cell classification and report that classically defined cDC2s contain a discrete population of monocyte-derived migratory antigen-presenting cells with Mϕ phenotype but functional DC features, including cross-presentation.

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Teaser

Sheng et al. describe a distinct subset of migratory antigen-presenting cells that share features characteristic of both cDC2s and macrophages. Their numbers are markedly increased in tumors, where they are able to cross-present tumor antigens, thus representing an important addition to the arsenal of known antigen-presenting cells.


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