A photochemical flow reactor for large scale syntheses of aglain and rocaglate natural product analogues

Publication date: 1 December 2017
Source:Bioorganic & Medicinal Chemistry, Volume 25, Issue 23
Author(s): Han Yueh, Qiwen Gao, John A. Porco, Aaron B. Beeler
Herein, we report the development of continuous flow photoreactors for large scale ESIPT-mediated [3+2]-photocycloaddition of 2-(p-methoxyphenyl)-3-hydroxyflavone and cinnamate-derived dipolarophiles. These reactors can be efficiently numbered up to increase throughput two orders of magnitude greater than the corresponding batch reactions.

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