Publication date: Available online 9 November 2017
Source:Human Pathology
Author(s): Gregory R Bean, Kwun Wah Wen, Andrew E Horvai
Among well-differentiated lipomatous lesions, variability in adipocyte size has been proposed as a morphologic feature of malignancy. Specifically, normal adipose tissue and benign lipomas tend to contain adipocytes of uniform size, whereas atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) are described as containing adipocytes with a conspicuous variation in cell size. However, this proposed variance has never been objectively, quantitatively correlated with diagnosis. Using whole slide scanning combined with semiautomated digital image analysis, we aimed to quantitatively test the hypothesis that variance in adipocyte size is a feature of malignancy in well-differentiated lipomatous tumors. Whole slide scanning was performed on representative hematoxylin and eosin-stained slides selected from 130 cases representing benign (lipoma, spindle cell lipoma) and malignant lipomatous neoplasms (ALT/WDL) and morphologic mimics (normal adipose tissue, fat necrosis, fat atrophy). A previously validated, open-source software package (Fiji-based Adiposoft) was used in semiautomated analysis of adipocyte size from a representative 1cm2 portion of each slide. Median, range, and variance of cell sizes was compared across all diagnoses. Fat atrophy demonstrated smaller adipocyte cell size compared to other diagnoses. Among the remaining diagnostic groups, no significant differences were identified in adipocyte size or variance by objective quantitative morphologic analysis. However, the maximum range of adipocyte size was significantly higher in ALT/WDL than conventional lipoma and spindle cell lipoma. These data quantitate the morphology of ALT/WDL and its mimics and more specifically defines the somewhat subjective "variability" of cell size as maximum range, rather than variance, of adipocyte size.
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Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Τετάρτη 15 Νοεμβρίου 2017
Adipocyte Size Variability in Benign and Malignant Lipomatous Tumors and Morphologic Mimics: a Quantitative Definition Using Digital Pathology
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