Publication date: Available online 6 November 2017
Source:Journal of the American Academy of Dermatology
Author(s): Bruce Strober, Melinda Gooderham, Elke M.G.J. de Jong, Alexa B. Kimball, Richard G. Langley, Nikita Lakdawala, Kavitha Goyal, Fabio Lawson, Wayne Langholff, Lori Hopkins, Steve Fakharzadeh, Bhaskar Srivastava, Alan Menter
BackgroundPatients with psoriasis are at an increased risk for depression. However, the impact of treatment on this risk is unclear.ObjectiveEvaluate the incidence and impact of treatment on depression among patients with moderate-to-severe psoriasis.MethodsWe defined a study population within the Psoriasis Longitudinal Assessment and Registry and measured the incidence of depressive symptoms (Hospital Anxiety and Depression Scale–Depression score ≥8) and adverse events (AEs) of depression within cohorts receiving biologics, conventional systemic therapies, or phototherapy. Patients were evaluated at approximately 6-month intervals. Multivariate modeling determined the impact of treatment on risk.ResultsThe incidence rates of depressive symptoms were 3.01 per 100 patient-years (PYs) (95% confidence interval [CI], 2.73-3.32), 5.85 per 100 PYs (95% CI, 4.29-7.97), and 5.70 per 100 PYs (95% CI, 4.58-7.10) for biologics, phototherapy, and conventional therapy, respectively. Compared with conventional therapy, biologics reduced the risk for depressive symptoms (hazard ratio, 0.76; 95% CI, 0.59-0.98), whereas phototherapy did not (hazard ratio, 1.05; 95% CI, 0.71-1.54). The incidence rates for AEs of depression were 0.21 per 100 PYs (95% CI, 0.15-0.31) for biologics, 0.55 per 100 PYs (95% CI, 0.21-1.47) for phototherapy, and 0.14 per 100 PYs (95% CI, 0.03-0.55) for conventional therapy; the fact that there were too few events (37 AEs) precluded modeling.LimitationsIncomplete capture of depression and confounders in the patients on registry.ConclusionCompared with conventional therapy, biologics appear to be associated with a lower incidence of depressive symptoms among patients with psoriasis.
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Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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Δευτέρα 6 Νοεμβρίου 2017
Depressive symptoms, depression, and the effect of biologic therapy among patients in Psoriasis Longitudinal Assessment and Registry (PSOLAR)
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- Photoluminescent properties of single crystal diam...
- Does the reduction of inferior turbinate size affe...
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- A case of segmental stiff skin syndrome treated wi...
- CONTENTS 1
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- Direct Observation vs. Video-Based Assessment in F...
- Characterization of Vessel Deformations During EVA...
- Analysis of Academic Medical Center Graduate Medic...
- 360° Operative Videos: A Randomised Cross-Over Stu...
- Textual Analysis of General Surgery Residency Pers...
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- Vitamin D, the placenta and early pregnancy: effec...
- Visible-light-driven photocatalytic inactivation o...
- Encapsulation of fluorescein into nanozeolites L a...
- Utilization of red mud and Pb/Zn smelter waste for...
- A novel method of utilization of hot dip galvanizi...
- A detailed study on Sn4+ doped ZnO for enhanced ph...
- Zn nanoparticle formation in FIB irradiated single...
- Effects of the carrier concentration on polarity d...
- Evaluating the diffusive gradients in thin films t...
- Soil geochemical factors regulate Cd accumulation ...
- Study of the iron nitride FeN into the megabar regime
- Public health approach to minimize the prevalence ...
- Necessity to strengthen prevention activities and ...
- The effect of space face games on the amount of ch...
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- Single-Neuron Correlates of Awareness during Atten...
- Parallel Distributed Processing Theory in the Age ...
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