Functional MR Imaging: Blood Oxygen Level–Dependent and Resting State Techniques in Mild Traumatic Brain Injury

Publication date: February 2018
Source:Neuroimaging Clinics of North America, Volume 28, Issue 1
Author(s): Scott Rosenthal, Matthew Gray, Hudaisa Fatima, Haris I. Sair, Christopher T. Whitlow

Teaser

This article discusses mild traumatic brain injury (mTBI)-associated effects on brain functional connectivity assessed via resting-state functional MR (fMR) imaging. Several studies have reported acute post-injury default mode network hyperconnectivity, followed by a period of decreased connectivity before later connectivity normalization in some patients. Other studies have reported mTBI associated effects on connectivity that remain evident for up to 5-years or more. Discordance in the published literature regarding the direction of network connectivity changes (eg, increased versus decreased connectivity) may reflect differences in timing of data collection post-injury, as well as the need to standardize MR imaging acquisition protocols and processing methods.


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