Half-sandwich ruthenium(ii) complexes containing N^N-chelated imino-pyridyl ligands that are selectively toxic to cancer cells.

Half-sandwich ruthenium(ii) complexes containing N^N-chelated imino-pyridyl ligands that are selectively toxic to cancer cells.

Chem Commun (Camb). 2017 Nov 16;:

Authors: Tian M, Li J, Zhang S, Guo L, He X, Kong D, Zhang H, Liu Z

Abstract
Chemotherapy is limited by its poor selectivity towards cancer cells over normal cells. Herein, we designed half-sandwich ruthenium imino-pyridyl complexes [(η(6)-bz)Ru(N^N)Cl]PF6 to achieve selective cytotoxicity to cancer cells. This kind of ruthenium complex has unique characteristics and is worthy of further exploration in the design of new anticancer drugs.

PMID: 29143019 [PubMed - as supplied by publisher]

http://ift.tt/2iqweVg