Publication date: Available online 10 November 2017
Source:Seminars in Oncology
Author(s): Sarada Achyutuni, Revathy Nadhan, Satheesh Kumar Sengodan, Priya Srinivas
Chromosome 17 (Chr17) harbors crucial genes that encode proteins implicated in a variety of cancers including some that guard cancer cells from genomic instability and others that interfere with metastasis. Included amongst the genes on chr17 that regulate biological processes fundamental to the genesis of cancer are TP53, BRCA1, CCL5, NF-1, and GRB7. As many as 50% of all human tumors and at least 30% of breast carcinomas contain p53 mutations, while 30-40% of breast cancers have defective BRCA1. A large number of proteins regulate the expression of these cancer genes on chr17 with miRNAs, the most widely studied class of regulatory RNAs, playing a major role in epigenetically controlling the gene expression programs, thereby managing various cellular functions. This review provides information on the genes transcribed from chr17, and their regulation by miRNAs in the context to tumorigenesis located on chr17, along with an analysis of the receptor status [estrogen (ER), progesterone (PR) and Her2/Neu] from the miRNA prediction data of miRNA genes located on chr17.
http://ift.tt/2AuGhiq
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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Παρασκευή 10 Νοεμβρίου 2017
The Prodigious Network of Chromosome 17 miRNAs Regulating Cancer Genes that Influence the Hallmarks of Cancer
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- Expression and functional characterization of tach...
- A systematic review of secondary cerebrospinal flu...
- Beyond borders and sinuses: Rhinology and allergy ...
- The role of regulatory T cells in the regulation o...
- Sinonasal T-cell expression of cytotoxic mediators...
- Role of adenosine monophosphate‐activated protein ...
- Effectiveness of intranasal sodium hyaluronate in ...
- Gender-specific differences in serum immunoglobuli...
- The relationship between social determinants of he...
- Biocompatibility and pharmacokinetics of fluticaso...
- Role of exhaled nasal nitric oxide in distinguishi...
- Vitamin D3 deficiency and its association with nas...
- Influence of chitosan-based dressing on prevention...
- Endonasal endoscopic management of frontal sinus c...
- Comparison of two concentrations of triamcinolone ...
- Factors that contribute to disagreement in satisfa...
- Acute radiology rarely confirms sinus disease in s...
- Editorial Board ((ofc))
- Quercetin protects jejunal mucosa from experimenta...
- Differences in self-advocacy among hard of hearing...
- Absence of delay in spontaneous use of gestures in...
- Contrast-enhanced imaging features and differentia...
- Benefit and clinical significance of retrospective...
- Author index∗∗July, pp. 1-196; August, pp. 197-390...
- Subject index
- Editorial Board
- Topical 15% resorcinol for hidradenitis suppurativ...
- The water-drop test for the diagnosis of koilonychia
- Doctors' mental health, burnout, and suicidality: ...
- Cover Sheet for Index
- Circumventing iPLEDGE: Circumventing ethical respo...
- Injection of filler for volume replacement of the ...
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- Lymphedema
- A novel clinical sign to aid in the diagnosis of s...
- Inpatient dermatology consultations: Motivation an...
- The hungry caterpillar flap: A variant of the V-to...
- Information for Readers
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- High-risk category for early annual ophthalmology ...
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- The cover page
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- A longitudinal study of retinal nerve fibre layer ...
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- Unexpected cause of leg pain in a patient with low...
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