Publication date: January 2018
Source:Dental Materials, Volume 34, Issue 1
Author(s): Falk Schwendicke, Niek Opdam
ObjectiveClinical studies should be one main aspect underlying dentists' decision-making towards dental materials. Study design, conduct, analysis and reporting impact on the usefulness of studies. We discuss problems with current studies and highlight areas where improvement might be possible.MethodsBased on systematically and non-systematically collected data, we demonstrate where and why current studies in clinical dentistry deliver less-than-optimal results. Lending from general medicine, we suggest ways forward for clinical dental material science.ResultsRandomized controlled (efficacy) trials remain a major pillar in dental material science, as they reduce selection bias and, if well-designed and conducted, have high internal validity. Given their costs and limited external validity, alternatives like practice-based or pragmatic controlled trials or observational studies can complement the evidence-base. Prior to conduct, researchers should focus on study comparators and setting (answering questions with relevance to clinical dentistry), and pay attention to statistical power, considering the study aim (superiority or non-inferiority trial), the expected event rate, and attrition. Study outcomes should be chosen on the basis of a core outcome set or, if not available, involving patients and other stakeholders. Studies should be registered a priori, and reporting should adhere to standards. Possible clustering should be accounted for during statistical analysis.SignificanceMany clinical studies in dental material science are underpowered, and of limited validity and usefulness for daily decision-making. Dental researchers should mirror existing efforts in other medical fields in making clinical studies more valid and applicable, thus contributing to better dental care.
http://ift.tt/2ByNumC
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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! # Ola via Alexandros G.Sfakianakis on Inoreader
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Παρασκευή 22 Δεκεμβρίου 2017
Clinical studies in restorative dentistry: Design, conduct, analysis
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- Removal of thyroid remnant for cancer in the previ...
- Recurrent laryngeal nerve preservation in thyroid ...
- A rare cause of neonatal persistent jaundice
- Maxillary chondrosarcoma mimicking torus palatinus
- Intractable hyperemesis gravidarum in a patient wi...
- Intradural lumbar disc herniation detected by 3D C...
- Shah-Waardenburg syndrome: a case highlighting the...
- Solid pseudopapillary tumour (Frantzs tumour) of t...
- Unusual case of anxiety: trichloroethylene neuroto...
- Cutaneous infection with paucibacillary Mycobacter...
- Short-course high-dose ibuprofen causing both earl...
- Oyster-related tenosynovitis: a rare case of Mycob...
- HHV-8-associated haemophagocytic lymphohistiocytos...
- Chickenpox: an ageless disease
- Osteoid bezoar: a rare case causing small bowel ob...
- Syndrome of X linked intellectual disability, epil...
- Idiopathic bilateral hypertrophic olivary degenera...
- Contemporary non-surgical approach for faecal dive...
- Variant of Lemierres syndrome with internal jugula...
- Correction: Gangrenous digital infarcts in a sever...
- Double hit! A unique case of resistant hypertension
- Epstein–Barr virus exanthem in an adult patient wi...
- Ischaemic ulcers on the toes secondary to Raynaud ...
- Morphologic and mechanical properties of blends fr...
- Nano-mechanical properties of interphases in dynam...
- Putative role of attractive and repulsive forces i...
- Performance of high lignin content cellulose nanoc...
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- A drip-crosslinked tough hydrogel
- Polyurethane-silica nanocomposites provided from p...
- The nature of bonding matters: Benzoxazine based s...
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- Soluble, porous semifluorinated poly(arylene ether...
- Self-crosslinkable nitroxide-functionalized poly(2...
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- Response to the Letter to the Editor-in-Chief on M...
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- Repeatability of Contrast-Enhanced Ultrasonography...
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- A Novel Method of Synovitis Stratification in Ultr...
- Ultrasound Determination of the Femoral Head-Neck ...
- 3D spatially-adaptive canonical correlation analys...
- The role of the cerebellum in explicit and inciden...
- Desert actinobacteria as a source of bioactive com...
- Multifarious plant growth promotion by an entomopa...
- For the greater good: Programmed cell death in bac...
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- Osteon Myospalacem Baileyi attenuates osteoclast d...
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- A review of the traditional and modern uses of Sal...
- Extraction, fractionation and re-fractionation of ...
- The Japanese Angelica acutiloba root and yokukansa...
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- Novel POFUT1 mutation associated with hidradenitis...
- The insular cortex and QTc interval in HIV+ and HI...
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- Oxyneurography: A non-invasive NIRS technique to m...
- Neurophysiology and cognitive reserve: A promising...
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- Reply to “Stimulus, response and excitability – Wh...
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- A real-world, community-based cohort study compari...
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