Delayed clinical complete response to intensity-modulated radiotherapy in nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is a common head and neck cancer in China, especially the southern regions, with 60,600 new cases reported in 2015 [1]. Unlike other head and neck cancers, radiotherapy (RT) is the primary treatment modality for non-disseminated NPC due to its anatomical location and sensitivity to radiation. The optimal time-point for assessing the tumor response to RT is very important in NPC, as it determines whether the patient has residual or persistent disease and whether salvage treatment should be initiated [2–4].

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