Implications of Clostridium septicum in Vascular Surgery: A Case Report and Outcomes Literature Review.

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Implications of Clostridium septicum in Vascular Surgery: A Case Report and Outcomes Literature Review.

Ann Vasc Surg. 2017 Aug;43:314.e5-314.e11

Authors: Alimi Y, Sosin M, Borsinger TM, Garrett JR, Salameh JR, Espinel CF

Abstract
Clostridium septicum is a rare organism, accounting for approximately 1.3% of clostridial infections and is associated with synchronous colonic malignancy. This case report describes a patient successfully treated for a mycotic aortic aneurysm secondary to C. septicum bacteremia. Subsequent evaluation confirmed a colonic malignancy, prompting early intervention. A systematic literature review revealing a rate of gastrointestinal malignancy in this patient population is 71%, and hematologic malignancy is 3.9%, with the remaining cohort of patients having an unknown source. Infectious involvement of the aorta and associated vascular structures portends a poor prognosis with a 57% mortality rate. Our case and updated review demonstrates the implications of C. septicum vascular seeding and subsequent treatment outcomes.

PMID: 28479472 [PubMed - indexed for MEDLINE]

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