Multiple Nonleukemic Myeloid Sarcoma Associated Hemophagocytic Lymphohistiocytosis in an Adult.

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Multiple Nonleukemic Myeloid Sarcoma Associated Hemophagocytic Lymphohistiocytosis in an Adult.

Clin Lab. 2017 Nov 01;63(11):1919-1922

Authors: Zhang J, Zeng Y, Zhang X, Lai W, Chen Y, Xiao R

Abstract
BACKGROUND: Nonleukemic myeloid sarcoma (MS) occurs rarely. Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal condition. We report a rare case of nonleukemic MS associated with HLH.
METHODS: Hematologic investigation, 18F-FDG PET/CT, bone marrow aspirate and biopsy, and lymph node biopsy were performed in a 25-year-old male patient.
RESULTS: The patient was given a short-term treatment of etoposide and dexamethasone to control HLH. Then he received chemotherapy and responded well.
CONCLUSIONS: It is important to find the underlying cause of HLH in high-risk patients. HLH can occur secondary to nonleukemic MS. Early diagnosis and treatment can improve survival.

PMID: 29226650 [PubMed - in process]

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