Publication date: Available online 14 December 2017
Source:Medical Hypotheses
Author(s): Aleisha.R. Brock, Joshua.V. Ross, Sunil Parikh, Adrian Esterman
The emergence and transmission of antimalarial resistance is hampering malaria eradication efforts and is shortening the useful therapeutic life of currently available antimalarials. Drug selection pressure has been identified as a contributing factor to the emergence and transmission of resistance, especially population treatment coverage and sub-therapeutic concentrations of active pharmaceutical ingredient (API) in the bloodstream. Medicine quality can be defined as good quality or poor quality. Poor quality antimalarials can be falsified, substandard or degraded and are estimated to make up between 10-50% of the antimalarial market in developing countries, and can be a source of sub-therapeutic doses of antimalarial API(s). The availability and use of poor quality antimalarials and the non-recommended use of quality assured monotherapies have historically been linked to treatment failure and in some cases, have coincided with the emergence and transmission of resistance in regions. We propose and outline the hypotheses that the use of poor quality antimalarial treatments and non-recommended quality assured monotherapies promote the (i) emergence and/or (ii) transmission of antimalarial resistance.
http://ift.tt/2Cp6Si5
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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- Supported carbon dots serve as high-performance ad...
- Preliminary survey of matrix effects in the Microw...
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- Theta-burst modulation of mid-ventrolateral prefro...
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- Editorial Board
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- Hepatocellular carcinoma in the era of immunotherapy
- Locally advanced pancreatic cancer: An emerging en...
- Is the limit of 60mg of oral morphine equivalent d...
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- Title Page
- Information for Readers
- Table of Contents
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- Complications in the treatment of mandibular condy...
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- Editorial Board
- OBC
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