Whole Body Periodic Acceleration (pGz) as a Non-Invasive Preconditioning Strategy for Pediatric Cardiac Surgery

Publication date: Available online 5 December 2017
Source:Medical Hypotheses
Author(s): Jose A. Adams, Peter Pastuszko, Arkady Uryash, David Wilson, Jose R. Lopez Padrino, Vinay Nadkarni, Anna Pastuszko
We hypothesized that pGz has cardio and neuroprotective effects due to upregulation of pathways which include eNOS, anti-apoptotic, and anti-inflammatory pathways. We analyze protein expression of these pathways in the brain of neonatal piglets, as well as report on the myocardial function after Deep Hypothermic Circulatory Arrest (DHCA) and pGz preconditioning. Animal data affirms both a cardio and neuroprotective role for pGz. These findings suggest that pGz can be a simple, non-invasive cardio and neuroprotective strategy preconditioning strategy in children requiring surgical intervention.



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