Biofilms busters to improve the detection of Borrelia using PCR

Publication date: March 2018
Source:Medical Hypotheses, Volume 112
Author(s): Alexis Lacout, Véronique Dacher, Mostafa El Hajjam, Pierre Yves Marcy, Christian Perronne
Lyme disease is an affection caused by a spirochete infection called Borrelia Burgdorferi which may harbor a varied and misleading clinical symptomatology. The serology tests commonly used for diagnosis show a wide sensitivity varying from 34% to 70,5%, leaving many infected patients with false negative tests. Alternative techniques such as polymerase chain reaction (PCR) could be helpful but not conclusive enough. Using biofilm busters, such as stevia and serratiopeptidase, could lead to bacterial blood release, thus increasing the spirochete load, making PCR test more sensitive, thus improving the patient's diagnosis and management.



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