Comparison of treatment of basal cell carcinoma between surgery and intralesional photodynamic therapy: a cross-sectional study

Publication date: Available online 5 January 2018
Source:Photodiagnosis and Photodynamic Therapy
Author(s): M.J. Suárez Valladares, J. Vega, M.A. Rodríguez Prieto
BackgroundSurgery is the treatment of choice in basal cell carcinoma (BCC), but new less invasive techniques are in development as photodynamic therapy. The main problem of this technique is the limited penetration. The use of an intralesional photosensitizer plus an irradiation with a 630 nm laser increased this penetration.ObjetivesTo compare the effectiveness in treatment of BCC between surgery and intralesional photodynamic therapy (I-PDT). To identify the clearance rate differences between intralesional or external irradiation in I-PTD group.MethodsA retrospective study of 102 patients with different histological types of BCC (mean depth of 2.44 mm) was performed. 51 patients were treated with surgery and 51 with I-PDT, injecting 5-aminolevulinic acid 1% in the tumor and later irradiated with a 630 nm laser (intralesionally or externally 25 and 26 patients respectivelly). Histological samples were obtained before and after treatment.Results41/51 patients in surgery group vs 42/51 patients in I-PDT group achieved a complete clearance after treatment (p 0.79). There were no differences in success rates between intralesional vs external irradiation in I-PDT group (p 0.46).Limitationssmall sample size and retrospective study.ConclusionI-PDT achieved high clearance rates in the treatment of BCC similar to surgery. There were no differences in success rates between intralesional vs external irradiation in I-PDT group. It might be an interesting option of treatment where surgery it is not possible.



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