Interleukin-33 induces mucin gene expression and goblet cell hyperplasia in human nasal epithelial cells.

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Interleukin-33 induces mucin gene expression and goblet cell hyperplasia in human nasal epithelial cells.

Cytokine. 2017 Feb;90:60-65

Authors: Ishinaga H, Kitano M, Toda M, D'Alessandro-Gabazza CN, Gabazza EC, Shah SA, Takeuchi K

Abstract
We investigated whether IL-33 is involved in mucus overproduction and goblet cell hyperplasia in eosinophilic chronic rhinosinusitis (ECRS). IL-33 mRNA was significantly higher in the eosinophilic CRS group than in the non-eosinophilic CRS group from human nasal polyps. IL-33 induced MUC5AC mRNA and MUC5AC protein, and also goblet cell hyperplasia at air liquid interface culture in human nasal epithelial cells. In addition to that, IL-33 induced MUC5B and FOXA3, and reduces FOXJmRNA. In conclusion, our present study demonstrated that the direct evidence of IL-33 which lead to increase mucin gene and protein expression, as well as goblet cell hyperplasia. This study provides novel insights into the role of IL-33 on mucus overproduction in eosinophilic inflammation of human airways.

PMID: 27776277 [PubMed - indexed for MEDLINE]

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