Management of Reticular Oral Lichen Planus patients with Burning Mouth Syndrome-like oral symptoms: a pilot study.

Management of Reticular Oral Lichen Planus patients with Burning Mouth Syndrome-like oral symptoms: a pilot study.

J Dermatolog Treat. 2018 Jan 08;:1-24

Authors: Adamo D, Mignogna MD, Pecoraro G, Aria M, Fortuna G

Abstract
OBJECTIVES: We sought to determine the efficacy of psychotropic drug in the management of BMS-like oral symptoms in patients with reticular oral lichen planus (R-OLP) refractory to conventional therapies, and its impact on anxious and depressive symptoms.
MATERIALS AND METHODS: We enrolled 28 cases of symptomatic R-OLP. The Numeric Rating Scale (NRS), the Total Pain Rating Index (T-PRI), the Hamilton rating scales for Depression (HAM-D) and Anxiety (HAM-A) were performed at baseline (time 0), after 2 months of topical clonazepam (time 1) and after six months of benzodiazepine and antidepressant drugs (time 2).
RESULTS: R-OLP patients showed a statistically significant improvement in the NRS and T-PRI scores from time 0 [Median: 9.0 (IQR: 7.2-10.0) and 10.5 (IQR: 7.0-13.0), respectively] to time 2 [(Median: 2.0 (IQR: 2.0-3.0) (p< 0.001) and 3.0 (IQR: 2.0-4.7) (p< 0.001), respectively]. Similarly, the HAM-A and HAM-D scores showed an improvement from time 0 [(Median: 15.0 (IQR: 10.2-17.8) and 13.0 (IQR: 12.0-15.0), respectively] to time 2 [Median: 6.0 (IQR: 4.0-7.0) (p< 0.001) and 5.5 (IQR: 4.25-6.0) (p< 0.001), respectively].
CONCLUSIONS: Psychotropic drugs turned out to be effective in the management of BMS-like oral symptoms in R-OLP patients refractory to conventional immunosuppressive therapy, although in a long-term period.

PMID: 29308937 [PubMed - as supplied by publisher]

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