Multiproteinopathy, neurodegeneration and old age: a case study.

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Multiproteinopathy, neurodegeneration and old age: a case study.

Neurocase. 2018 Jan 06;:1-6

Authors: Rojas JC, Stephens ML, Rabinovici GD, Kramer JH, Miller BL, Seeley WW

Abstract
A complex spectrum of mixed brain pathologies is common in older people. This clinical pathologic conference case study illustrates the challenges of formulating clinicopathologic correlations in late-onset neurodegenerative diseases featuring cognitive-behavioral syndromes with underlying multiple proteinopathy. Studies on the co-existence and interactions of Alzheimer's disease (AD) with neurodegenerative non-AD pathologies in the aging brain are needed to understand the pathogenesis of neurodegeneration and to support the development of diagnostic biomarkers and therapies.

PMID: 29307276 [PubMed - as supplied by publisher]

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