Nonsurgical management of human immunodeficiency virus-associated parotid cysts: A systematic review and meta-analysis.

Nonsurgical management of human immunodeficiency virus-associated parotid cysts: A systematic review and meta-analysis.

Head Neck. 2018 Jan 12;:

Authors: Naik AN, Clinkscales WB, Kato MG, Nguyen SA, Gillespie MB

Abstract
BACKGROUND: The purpose of this clinical review was to analyze the effectiveness of nonsurgical management options for human immunodeficiency virus (HIV)-associated parotid cysts.
METHODS: We conducted systematic and meta-analysis reviews. Primary outcomes were complete or partial responses.
RESULTS: Systematic review identified 12 relevant studies. The average rates of complete response for antiretroviral therapy (ART), sclerotherapy, and fine-needle aspiration (FNA) were 52.8%, 55.5%, and 33.3%, respectively. Three radiotherapy studies, totaling 104 patients, were included in a meta-analysis. Patients receiving high-dose therapy achieved complete and partial response rates of 65.8% (95% confidence interval [CI] 54.3%-76.2%) and 25.2% (95% CI 16.1%-36.3%), respectively. Patients receiving low-dose therapy achieved complete and partial response rates of 23.2% (95% CI 1.2%-60.9%) and 22.3% (95% CI 5.2%-87.8%), respectively. The rate of complete response was significantly greater for high-dose radiotherapy compared to low-dose (P < .001).
CONCLUSION: Among nonsurgical treatment modalities for HIV-associated parotid cysts, radiotherapy has the highest number of reported outcomes in the literature and our analysis suggests that higher dose radiotherapy has higher rates of achieving complete response.

PMID: 29327783 [PubMed - as supplied by publisher]

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