Prognostic Factors for the Survival Outcome of High-grade Multicentric Glioma.

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Prognostic Factors for the Survival Outcome of High-grade Multicentric Glioma.

World Neurosurg. 2018 Jan 11;:

Authors: Wang T, Niu X, Gao T, Zhao L, Li J, Gan Y, Liu Y, Mao Q

Abstract
OBJECTIVE: The purpose of this study was to perform an survival analysis of patients with high-grade multicentric gliomas and to assess the influence of various prognostic factors on overall survival.
METHODS: A literature search on PubMed and Web of Science was performed for literature in English published from 1880 to October 2017. Detailed information including demographics, clinical characteristics, treatments, critical events, and time to events for survival analysis were extracted from the included articles.
RESULTS: A total of 73 cases from 25 published articles were selected for analysis. Univariate analysis showed the surgery (SB/SR), age(<54/≥54years), radiotherapy (Y/N) and supra-infratentorial gliomas (Y/N) had significant correlations with overall survival. Multivariate analysis showed that age, surgery and radiotherapy were independent prognostic factors. Univariate and multivariate analysis revealed radiotherapy and radiotherapy combined chemotherapy were independent prognostic factors for surgical patients' overall survival.
CONCLUSIONS: This comprehensive analysis of multicentric gliomas patients revealed that age younger than 54 years, surgical resection and radiotherapy were significantly associated with improved survival and were independent prognostic factors for overall survival. Radiotherapy and radiotherapy combined chemotherapy were independent prognostic factors for surgical patients' overall survival as well.

PMID: 29337167 [PubMed - as supplied by publisher]

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