The clinicopathological features and prognosis of tumor MSI in East Asian colorectal cancer patients using NCI panel.

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The clinicopathological features and prognosis of tumor MSI in East Asian colorectal cancer patients using NCI panel.

Future Oncol. 2018 Jan 25;:

Authors: Zheng J, Huang B, Nie X, Zhu Y, Han N, Li Y

Abstract
AIM: To compare test results obtained from a PCR assay for the National Cancer Institute (NCI) five loci criteria for detecting microsatellite instability (MSI) with those obtained from immunohistochemistry of mismatch repair and a five-mononucleotide site amplification system in East Asian patients with colorectal cancer.
PATIENTS & METHODS:  A total of 245 East Asian patients with colorectal cancer were studied retrospectively at our institution.
RESULTS: The consistency of the NCI panel PCR method compared with detection of mismatch repair protein expression by immunohistochemistry was 0.898. High level MSI (MSI-H) status was correlated with the Tumor, Node, Metastasis stage, tumor location site, metastasis, tumor grade, mucinous histological type and BRAF-type mutations.
CONCLUSION: The NCI panel PCR assay has excellent sensitivity and specificity for detecting MSI in an East Asian population.

PMID: 29366338 [PubMed - as supplied by publisher]

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