The Role of Preoperative Steroids for Hearing Preservation Cochlear Implantation: Results of a Randomized Controlled Trial.

The Role of Preoperative Steroids for Hearing Preservation Cochlear Implantation: Results of a Randomized Controlled Trial.

Audiol Neurootol. 2018 Jan 13;22(4-5):292-302

Authors: Kuthubutheen J, Joglekar S, Smith L, Friesen L, Smilsky K, Millman T, Ng A, Shipp D, Coates H, Arnoldner C, Nedzelski J, Chen J, Lin V

Abstract
OBJECTIVES: To determine whether preoperative steroids can improve hearing outcomes in cochlear implantation (CI).
METHODS: This is a randomized controlled trial involving 30 postlingual deaf CI patients. Subjects had preoperative thresholds of better than or equal to 80 dB at 125 and 250 Hz, and better than or equal to 90 dB at 500 and 1,000 Hz. The subjects were randomized to a control group, an oral steroid group (receiving 1 mg/kg/day of prednisolone for 6 days prior to surgery), or a transtympanic steroid group (receiving a single dose of 0.5 mL of 10 mg/mL dexamethasone at 24 h prior to surgery).
RESULTS: The subjects receiving transtympanic steroids had a significant decrease in the pure tone average over 3 months compared to the control and oral steroid group, which persisted over 12 months (p < 0.05).
CONCLUSION: A single dose of preoperative transtympanic steroids prior to CI appears to have a beneficial effect, at least in the short term, with minimal effects seen in the longer term.

PMID: 29332068 [PubMed - as supplied by publisher]

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