Wild-type and mutated IDH1/2 enzymes and therapy responses.

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Wild-type and mutated IDH1/2 enzymes and therapy responses.

Oncogene. 2018 Jan 25;:

Authors: Molenaar RJ, Maciejewski JP, Wilmink JW, van Noorden CJF

Abstract
Isocitrate dehydrogenase 1 and 2 (IDH1/2) are key enzymes in cellular metabolism, epigenetic regulation, redox states, and DNA repair. IDH1/2 mutations are causal in the development and/or progression of various types of cancer due to supraphysiological production of D-2-hydroxyglutarate. In various tumor types, IDH1/2-mutated cancers predict for improved responses to treatment with irradiation or chemotherapy. The present review discusses the molecular basis of the sensitivity of IDH1/2-mutated cancers with respect to the function of mutated IDH1/2 in cellular processes and their interactions with novel IDH1/2-mutant inhibitors. Finally, lessons learned from IDH1/2 mutations for future clinical applications in IDH1/2 wild-type cancers are discussed.

PMID: 29367755 [PubMed - as supplied by publisher]

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