68Ga-DOTATATE PET/CT Reveals Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma in a Case of Suspected Sphenoid Wing Meningioma.

68Ga-DOTATATE PET/CT Reveals Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma in a Case of Suspected Sphenoid Wing Meningioma.

Clin Nucl Med. 2018 Feb 03;:

Authors: Unterrainer M, Maihoefer C, Cyran CC, Bartenstein P, Niyazi M, Albert NL

Abstract
In this case of suspected sphenoid wing meningioma, Ga-DOTATATE PET/CT showed a somatostatin receptor (SSR)-expressing tumor with extension to the nasopharynx and SSR-expressing cervical lymph nodes. Subsequent biopsy from the nasopharynx revealed an Epstein-Barr virus (EBV)-associated, undifferentiated World Health Organization type 3 nasopharyngeal carcinoma (NPC), a potential clinical pitfall due to the reported high SSR expression of this tumor subtype. In consideration of the high target-to-background contrast, SSR ligands might be superior to F-FDG for EBV-associated NPC PET imaging, particularly at the skull base. Somatostatin receptor ligands might furthermore offer interesting theranostic possibilities for patients with advanced/extensive EBV-associated NPC.

PMID: 29401153 [PubMed - as supplied by publisher]

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