[A Case of Anaplastic Carcinoma Spindle Cell Type of the Pancreas].

Related Articles

[A Case of Anaplastic Carcinoma Spindle Cell Type of the Pancreas].

Gan To Kagaku Ryoho. 2017 Nov;44(12):1745-1747

Authors: Fujita S, Matsukawa H, Shiozaki S, Satoh D, Idani H, Ojima Y, Harano M, Nakano K, Sumitani D, Choda Y, Ishida M, Miyake S, Kubota T, Okajima M

Abstract
Anaplastic carcinoma spindle cell type is an extremely rare disease and its prognosis is very poor. We herein report a case of anaplastic carcinoma spindle cell type of the pancreas. A 50-year-old man complaining of epigastralgia was found to have a pancreatic body-tail tumor by abdominal US and CT studies. Abdominal CT showed an irregular poorly-enhanced 33mm tumor containing a cystic component. ERCP revealed the main pancreatic duct was cut off at the tumor. Cytology of the pancreatic fluids did not indicate malignancy. A pancreatic tumor with a cystic component similar to pancreatic neoplasms containing cystic degeneration or a mass-forming pancreatitis concomitant with pancreatic pseudocyst was suspected. Therefore, we performed distal pancreatectomy. Histological findings showed the center of the tumor was severely necrotized and oval or spindle dysplastic cells proliferated around the peripheral area. According to the immunohistological staining pattern, the patient was diagnosed as having anaplastic carcinoma spindle cell type. He was administered oral S-1 for 6 months and is now recurrence-free, surviving for 15 months after pancreatectomy. Reports of long-term survival cases that also demonstrated R0 resection should be indicated in the treatment of anaplastic carcinoma spindle cell type despite the poor prognosis.

PMID: 29394762 [PubMed - in process]

http://ift.tt/2FRkaFD