Comparing Human and Mouse Salivary Glands: A Practice Guide for Salivary Researchers.

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Comparing Human and Mouse Salivary Glands: A Practice Guide for Salivary Researchers.

Oral Dis. 2018 Jan 30;:

Authors: Maruyama CL, Monroe M, Hunt J, Buchmann L, Baker OJ

Abstract
Mice are a widely utilized in vivo model for translational salivary gland research but must be used with caution. Specifically, mouse salivary glands are similar in many ways to human salivary glands (i.e., in terms of their anatomy, histology and physiology) and are both readily available and relatively easy and affordable to maintain. However, there are some significant differences between the two organisms, and by extension, the salivary glands derived from them that must be taken into account for translational studies. The current review details pertinent similarities and differences between human and mouse salivary glands and offers practical guidelines for using both for research purposes. This article is protected by copyright. All rights reserved.

PMID: 29383862 [PubMed - as supplied by publisher]

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