Dysbiosis of inferior turbinate microbiota is associated with high total IgE levels in allergic rhinitis patients.

Dysbiosis of inferior turbinate microbiota is associated with high total IgE levels in allergic rhinitis patients.

Infect Immun. 2018 Feb 05;:

Authors: Hyun DW, Min HJ, Kim MS, Whon TW, Shin NR, Kim PS, Kim HS, Lee JY, Kang W, Choi AMK, Yoon JH, Bae JW

Abstract
Abnormalities in the human microbiota are associated with the etiology of allergic diseases. Although disease site-specific microbiota may be associated with disease pathophysiology, the role of the nasal microbiota is unclear. We sought to characterize the microbiota of the site of allergic rhinitis, inferior turbinate, in subjects with allergic rhinitis (n=20) and healthy controls (n=12), and to examine the relationship of mucosal microbiota with disease occurrence, sensitized allergen number, allergen-specific- and total-IgE levels. Microbial dysbiosis correlated significantly with total IgE levels representing combined allergic responses, but not with disease occurrence, the number of sensitized allergens or house dust mite allergen-specific IgE levels. Comparing to individuals with low total IgE levels (group IgElow), low microbial biodiversity with high relative abundance of Firmicutes phylum (Staphylococcus aureus) and low relative abundance of Actinobacteria phylum (Propionibacterium acnes) were observed in individuals with high total serum IgE levels (group IgEhigh). Phylogeny-based microbial functional potential predicted by 16S rRNA gene indicated an increase in signal transduction-related genes and a decrease in energy metabolism-related genes in group IgEhigh as shown in the microbial features with atopic and/or inflammatory diseases. Thus, dysbiosis of the inferior turbinate mucosa microbiota, particularly an increase in S. aureus and a decrease in P. acnes, is linked to high total IgE levels in allergic rhinitis, suggesting that inferior turbinate microbiota may be affected by accumulated allergic responses against sensitized allergens and site-specific microbial alterations play a potential role in disease pathophysiology.

PMID: 29426044 [PubMed - as supplied by publisher]

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