Publication date: April 2018
Source:Biomedicine & Pharmacotherapy, Volume 100
Author(s): Mohamed A. Ibrahim, Walaa Yehia Abdelzaher, Remon R. Rofaeil, Soha Abdelwahab
Neuropathic pain is a worldwide health problem with no consensus regarding its optimal therapy. This study compared the analgesic effect and gastric, hepatic, and renal safety of combined low doses of diclofenac and celecoxib with gabapentin versus their individual high doses in the treatment of neuropathic pain in rats. Left sciatic nerve ligation was used as neuropathic pain model. Rats were allocated into 7 groups (7 rats for each): sham control; model group (received vehicle); Gaba-group (received gabapentin (100 mg/kg /day); Diclo 10-group (received diclofenac (10 mg/kg); Cele 10-group (received celecoxib (10 mg/kg/day); Gaba + Diclo 5 (receivedgabapentin(100 mg/kg /day) plus diclofenac (5 mg/kg); Gaba + Cele 5 (received gabapentin (100 mg/kg/day) plus celecoxib (5 mg/kg)). The analgesic effect was assessed using both hot plate and acetone tests. The impact of the used drugs on peptic ulcer index, liver enzymes, and serum urea and creatinine was evaluated, along with histopathological examination and oxidative stress parameters. Combination therapy of low dose of either diclofenac or celecoxib, with gabapentin showed higher analgesic effect compared with their individual high doses as indicated by prolonged response time in hot plate test and decreased frequency of paw withdrawal in acetone test. Their effect was associated with gentle effect on gastric mucosa, renal and hepatic integrity and oxidative stress parameters. In conclusion, the use of combined low doses of either diclofenac or celecoxib with gabapentin is better than high dose monotherapy regarding both the efficacy and safety.
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Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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Παρασκευή 16 Φεβρουαρίου 2018
Efficacy and safety of combined low doses of either diclofenac or celecoxib with gabapentin versus their single high dose in treatment of neuropathic pain in rats
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- Development of a stereoselective and scalable proc...
- Unprecedented sugar bridged bisindoles selective i...
- Discovery of 18β-glycyrrhetinic acid conjugated am...
- Editorial Board
- Graphical Abstract TOC continued
- Optimization of antimalarial, and anticancer activ...
- Post-Cardiac Arrest Management: Time to Cool It on...
- Targeted Temperature Management After Cardiac Arre...
- Perioperative Cardiac Arrest: Focus on Malignant H...
- Perioperative Cardiac Arrest: Focus on Local Anest...
- Perioperative Cardiac Arrest: Focus on Anaphylaxis
- Cardiac Arrest in the Operating Room: Part 2—Speci...
- Syndromic sebaceous nevus: current findings
- Eosinophilic polymorphic and pruritic eruption ass...
- Treatment optimization with secukinumab 150 mg for...
- Photobiomodulation (PBM) therapy at 904 nm mitigat...
- Targeted next-generation-sequencing for reliable d...
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- Zinc oxide nanotetrapods with four different arm m...
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- Exploiting CdSe/ZnS core-shell photocatalyst modif...
- Nivolumab-induced lichenoid dermatitis occurring i...
- Rapid improvement of nail matrix psoriasis with ap...
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- Rapid improvement of nail matrix psoriasis with ap...
- Objective assessment of the degree of improvement ...
- It has not been proven why or that most research f...
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- Subungual exostosis on index finger in a child
- Antihypertensives in dermatology Part II - Cutaneo...
- Total serum immunoglobulin E level and specific al...
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- Efficacy and safety of combined low doses of eithe...
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- Bryophyllum pinnatum inhibits arginase II activity...
- LncRNA-LET inhibits cell viability, migration and ...
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- Clinical Characteristics of Subtypes of Follicular...
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- In Response
- Perioperative Inflammation and Its Modulation by A...
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- In Response
- Post-Cardiac Arrest Management: Time to Cool It on...
- Efficacy Outcome Measures for Pediatric Procedural...
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- The Effect of Adductor Canal Block on Knee Extenso...
- Motor Evoked Potential Monitoring During Thoracoab...
- You’re Wrong, I’m Right: Dueling Authors Reexamine...
- In Response
- Anesthesia Advanced Cardiac Life Support: A Guidel...
- Perioperative Cardiac Arrest: Focus on Anaphylaxis
- Hyperglycemia and Elevated Lactate in Trauma: Wher...
- A Retrospective Analysis of Clinical Research Misc...
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