BACKGROUND Prasugrel is a thienopyridine that inhibits platelet aggregation more rapidly and effectively than clopidogrel, with an increased bleeding risk. OBJECTIVE The current study aimed to evaluate the efficacy of three nonspecific haemostatic drugs – recombinant activated factor VII (rFVIIa), tranexamic acid and desmopressin (DDAVP) – to limit blood loss after administration of prasugrel in a rabbit model of bleeding while also evaluating any prothrombotic effects. DESIGN Randomised, placebo-controlled study. SETTING Faculty of Medicine, University of Geneva, Switzerland, in 2013. ANIMALS Anaesthetised and artificially ventilated rabbits (n=56). INTERVENTIONS Animals were randomly allocated to one of five groups: control (placebo–placebo), prasugrel–placebo, rFVIIa (prasugrel–rFVIIa 150 μg kg−1), tranexamic acid (prasugrel–tranexamic acid 20 mg kg−1) or DDAVP (prasugrel–DDAVP 1 μg kg−1). Two hours after an oral prasugrel loading dose (4 mg kg−1), a stenosis and an injury were inflicted on the carotid artery to induce cyclic flow reductions (CFRs) due to thrombosis. Haemostatic drugs were administered during the ensuing observation period. MAIN OUTCOME MEASURES Standardised hepatosplenic sections were performed to evaluate the primary endpoint of blood loss, monitored for 15 min. Ear-immersion bleeding time and incidence of CFRs were secondary endpoints. RESULTS Prasugrel decreased ADP-induced platelet aggregation (light transmission method) from 66 ± 4% (mean ± SD) to 41 ± 7% (P
http://ift.tt/2DUwOU3
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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- An efficient method for eccrine gland isolation fr...
- Leiomyoma of the soft palate: Case report and revi...
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- A rotation flap does not rotate
- Does dietary fluid intake affect skin hydration in...
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- Editorial echoes
- The Vitamin D3 analogue calcipotriol suppresses Cp...
- Issue Information - TOC
- Issue Information - Cover
- Editorial echoes
- Comparison of the effectiveness of pulsed dye lase...
- Tracing Stem Cell Division in Adult Neurogenesis
- Slow Your Roll: Inhibiting SETD7 Activity Permits ...
- Shaping the Pluripotent Genome: Switches, Borders,...
- Mentoring the Next Generation: Irving Weissman
- Meddling with METTLs in Normal and Leukemia Stem C...
- Japan Strengthens Regenerative Medicine Oversight
- Phospholipid Remodeling and Cholesterol Availabili...
- Adult Neurogenesis Is Sustained by Symmetric Self-...
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- Progesterone arrested cell cycle progression throu...
- Vitamin D attenuates pressure overload-induced car...
- Selective estrogen receptor modulator ormeloxifene...
- Effect of vitamin D supplementation on serum scler...
- Development of a multivariate model of the six-min...
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- The Audiology of Otosclerosis
- Stapedectomy Versus Stapedotomy
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- Editorial Board
- The world needs new knowledge
- Low temperature diamond growth arising from ultraf...
- Radiomic Biomarkers to Refine Risk Models for Dist...
- The impact of HIV infection on survival and acute ...
- Effect of Radiation Treatment Volume Reduction on ...
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- The degradation and transport mechanism of a Mg-Nd...
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- The rheological properties of native sericin
- Interplay Between Stiffness and Degradation of Arc...
- Adhesive free-standing multilayer films containing...
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- Parámetros de cuantificación metabólica en la prác...
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- History of anaesthesia: Nurse anaesthesia practice...
- Reply to: emergency medicine is about collaboratio...
- Does the β-receptor antagonist esmolol have analge...
- Anaesthesiology and ethics: Can the anaesthesiolog...
- Standardised noxious stimulation-guided individual...
- Reply to: who takes the lead in critical illness?
- Neostigmine-based reversal of intermediate acting ...
- Reply to: collaboration in emergency medical care ...
- Effects of magnesium chloride on rocuronium-induce...
- Effects of propofol on wound closure and barrier f...
- Who takes the lead in critically ill patients?
- Professionalisation rather than monopolisation is ...
- Impact of pectoral nerve block on postoperative pa...
- Ultrasound with neurostimulation compared with ult...
- Ultrasound in Anesthesia, Critical Care, and Pain ...
- eNOS Uncoupling, A Therapeutic Target For Ischemic...
- Should platelet-rich plasma be activated in fat gr...
- Thermodynamic characterization of a non-commercial...
- Sonocatalytic degradation of rhodamine B in presen...
- I don't really feel comfortable doing that
- The way it was, the way it ought to be, the way it...
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- Surgery-first approach vs traditional approach
- February 2018:153(2)
- Authors' response
- Residents' journal review
- A friend in need
- Predictable method to deliver physiologic force fo...
- Reliability of different radiographic methods for ...
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