Inter-operator variability in compartmental kinetic analysis of 18F-fluoromisonidazole dynamic PET

Publication date: May–June 2018
Source:Clinical Imaging, Volume 49
Author(s): Sadek A. Nehmeh, Jazmin Schwartz, Milan Grkovski, Ivan Yeung, Charles M. Laymon, Mark Muzi, John L. Humm
PurposeTo assess the inter-operator variability in compartment analysis (CA) of dynamic-FMISO (dyn-FMISO) PET.MethodsStudy-I: Five investigators conducted CA for 23 NSCLC dyn-FMISO tumor time-activity-curves. Study-II: Four operators performed CA for four NSCLC dyn-FMISO datasets. Repeatability of Kinetic-Rate-Constants (KRCs) was assessed.ResultsStudy-I: Strong correlation (ICC > 0.9) and interchangeable results among operators existed for all KRCs. Study-II: Up to 103% variability in tumor segmentation, and weaker ICC in KRCs (ICC-VB = 0.53; ICC-K1 = 0.91; ICC-K1/k2 = 0.25; ICC-k3 = 0.32; ICC-Ki = 0.54) existed. All KRCs were repeatable among the different operators.ConclusionsInter-operator variability in CA of dyn-FMISO was shown to be within statistical errors.



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