New onset squamous cell carcinoma in previous split-thickness skin graft donor site.

New onset squamous cell carcinoma in previous split-thickness skin graft donor site.

Int J Surg. 2018 Feb 10;:

Authors: Noori VJ, Trehan K, Savetamal A, Carter DW

Abstract
INTRODUCTION: Marjolin' s ulcer, an aggressive ulcerating squamous cell carcinoma, is a well-known phenomenon that occurs in chronically inflamed or scarred tissue; however, squamous cell carcinoma arising in the acute setting after tissue trauma - specifically autograft donor harvest sites for burns - is a rare, but notable event.
METHODS: This case series describes three instances of squamous cell carcinoma diagnosed in split-thickness skin graft donor sites in the immediate post-operative period. Charts were reviewed in detail after at least 9 months follow-up from identification of the tumor. Detailed descriptions of each case are included. A discussion of the literature on this rare entity is included as well.
RESULTS: In the three cases discussed, all were characterized clinically as painful masses arising in a recently healed donor site. Two were managed surgically with adherence to oncologic principals. One lesion regressed or fell off spontaneously. With at least 9 months follow-up, there was no evidence of recurrence.
CONCLUSIONS: Very few cases of acute neoplasm in donor sites have been described in the literature. Presently, there is no dominant theory as to how these lesions arise; however, this is an entity that burn care providers - world wide-should be aware of, with a low threshold for oncologic evaluation if suspected.

PMID: 29438815 [PubMed - as supplied by publisher]

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