Publication date: 30 May 2018
Source:Biosensors and Bioelectronics, Volume 106
Author(s): Xiaobo Zhang, Yueyun Li, Hui Lv, Jinhui Feng, Zengqiang Gao, Ping Wang, Yunhui Dong, Qing Liu, Zengdian Zhao
Signal amplification is crucial for obtaining low detection limits in electrochemical immunosensor. In this work, we developed a novel signal amplification strategy using Au@Ag nanoparticles loaded by polydopamine functionalized phenolic resin microporous carbon spheres (Au@Ag/PDA-PR-MCS). Phenolic resin microporous carbon spheres (PR-MCS) possesses uniform size and a large surface area (1656.8 m2 g−1). Polydopamine (PDA) functionalized phenolic resin microporous carbon spheres (PDA-PR-MCS) retains the advantages of PR-MCS and possesses strong adsorption ability. With the unique structure of PDA-PR-MCS, it not only improves the loading capacity and dispersity of Au@Ag nanoparticles (Au@Ag NPs), but also enhances the stability for the combination of the Au@Ag NPs by chemical absorption between Au@Ag NPs and -NH2 of PDA. The Au@Ag/PDA-PR-MCS exhibits extraordinary electrocatalytic activity towards reduction of hydrogen peroxide (H2O2) to make the electrochemical response more sensitive. Furthermore, Au NPs with good biocompatibility and excellent conductivity were electrodeposited on the surface of electrode, which was used as a sensing platform to immobilize primary antibody (Ab1) and accelerate the electron transfer on the electrode interface. Herein, the designed immunosensor provided a broad linear range from 20 fg/mL to 100 ng/mL for alpha fetoprotein (AFP) detection and a low detection limit of 6.7 fg/mL (signal-to-noise ratio of 3) under optimal experimental conditions. Moreover, the excellent performance in detection of human serum samples indicated that the proposed immunosensor will provide promising applications in clinical monitoring of AFP.
http://ift.tt/2EDk7Ah
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Τρίτη 13 Φεβρουαρίου 2018
Sandwich-type electrochemical immunosensor based on Au@Ag supported on functionalized phenolic resin microporous carbon spheres for ultrasensitive analysis of α-fetoprotein
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- Using a Dihydrofolate Reductase-Based Strategy for...
- Anti-inflammatory activity and gastroprotective ef...
- Neuroprotective effect of Da Chuanxiong Formula ag...
- Beasley’s 1981 paper: The power of a well-designed...
- Asymptomatic facial nodules
- Characterization of oily mature skin by biophysica...
- Asymptomatic facial nodules
- Role of solid lipid nanoparticles as photoprotecti...
- Role of solid lipid nanoparticles as photoprotecti...
- Immunization with phage virus-like particles displ...
- FlaC supplemented with VAA, OmpK or OmpR as bivale...
- Exceptional influenza morbidity in summer season o...
- Turning up the heat: Effect of new vaccine for chi...
- The National Vaccine Advisory Committee at 30: Imp...
- Cost-effectiveness of vaccination against cytomega...
- Vaccination timeliness and co-administration among...
- Editorial Board/Aims and Scope
- Disparities in parental human papillomavirus (HPV)...
- Evaluation on the persistence of anti-HPV immune r...
- Influenza vaccine effectiveness in older adults co...
- Impact of introduction of the 9-valent human papil...
- Immune parameters to p67C antigen adjuvanted with ...
- Long-term immunogenicity of an initial booster dos...
- Routing dependent immune responses after experimen...
- Editorial Board/Aims and Scope
- The role of timeliness in the cost-effectiveness o...
- The impact of expanded program on immunization wit...
- Antigen-dependent effects of divergent selective b...
- Prevalence of Fructose Malabsorption in Patients W...
- Differential Emotional Processing in Concrete and ...
- Is Memory Better for Objects Than for Separate Sin...
- Influence of a mixture of metals on PAHs biodegrad...
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- Characterization and source identification of fine...
- Effect of Co doping on the magnetic and DC electri...
- The Visible Burrow System: A behavioral paradigm t...
- Pharmacological manipulation of GABA activity in n...
- Retina dose as a predictor for visual acuity loss ...
- Improved cost-effectiveness of short-course radiot...
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- Avoiding the Trap of Misdiagnosis: Valuable Teachi...
- [Spino-pelvic sagittal parameters in an asymptomat...
- [Invasive sinonasal papilloma with intracranial in...
- [Mild head injury].
- [Adult Grisel Syndrome and Cervical Skull instabil...
- [Minimally invasive extraforaminal lumbar interbod...
- Recent findings related to immune responses agains...
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- Bronchoalveolar Lavage Fluid in Children: Comparat...
- Impact of oxytetracycline and bacterial bioaugment...
- Halimeda jolyana (Bryopsidales, Chlorophyta) prese...
- Polyphenol extracts from dried sugarcane inhibit i...
- Proteomic characterization of Withaferin A-targete...
- Proteomic analysis of first trimester maternal ser...
- Impact of cephalosporin restriction on incidence o...
- Low Proportion of Dietary Plant Protein among Athl...
- Differences in Gut Microbiota Profiles between Aut...
- A Missense Mutation in GJA8 Encoding Connexin 50 i...
- Lymphaticovenular anastomosis for breast cancer tr...
- Aesthetic and functional outcomes of radial forear...
- Orchiectomy and letrozole differentially regulate ...
- Delayed Sleep Phase Syndrome and Bipolar Disorder:...
- Integrating plant and animal biology for the searc...
- Mutagenesis: Interactions with a parallel universe
- Cross-sectional associations between maternal self...
- The Great Esophageal Escape: A Case of Extreme Eso...
- Moonlighting? - Consequences of lunar cues on anur...
- The highs and lows of marijuana use in allergy
- Real world evaluation of a mobile health applicati...
- Sleep and Sedative States Induced by Targeting the...
- Examination of Utricular Response Using oVEMP and ...
- Ageing-related aorta remodelling and calcification...
- "Zhonghua Yi Xue Za Zhi"[jour]; +23 new citations
- Vitamin D modulatory effect on cytokines expressio...
- New technique for large mandibular and surrounding...
- Relationship Between Diet and Tinnitus: Korea Nati...
- Ageing-related aorta remodelling and calcification...
- Postoperative Antibiotics Following Cochlear Impla...
- upper respiratory tract infection; +51 new citations
- "Oncol Lett"[jour]; +257 new citations
- Innovative real CSF leak simulation model for rhin...
- Imaging Findings of Jugular Foramen Meningocele in...
- Sequential spinal and intracranial dural metastase...
- Utility of 3D printed models in enhancing the lear...
- Synthesis and characterization of Ag/Bi 2 WO 6 /GO...
- Lead-induced changes of cytoskeletal protein is in...
- Effect of H 2 O on the NO emission characteristics...
- The treatment of anti-phospholipid syndrome: A com...
- Nanofibers of resorcinol–formaldehyde for effectiv...
- Public awareness and knowledge of stuttering in Japan
- Shifting the Focus: The Primary Role of IL-23 in P...
- Do patients with p16-positive oropharyngeal squamo...
- Microbiology and antimicrobial susceptibility of o...
- A purely functional Imaging based approach for tra...
- Novel SGCE mutation in a patient with myoclonus-dy...
- The difficulty of predicting clinical outcome afte...
- Evaluation and management of small dural tears in ...
- Spinal primary central nervous system lymphoma: Ca...
- Rapid progressive visual decline and visual field ...
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