Value of 18F-FET PET in adult brainstem glioma

Publication date: September–October 2018
Source:Clinical Imaging, Volume 51
Author(s): Abdulrahman Abdullah Albatly, Adnan Taleb Alsamarah, Abdulrahman Alhawas, Patrick Veit-Haibach, Alfred Buck, Paul Stolzmann, Irene A. Burger, Spyros S. Kollias, Martin W. Huellner
PurposeTo investigate ¹⁸F-fluoro-ethyl-tyrosine positron emission tomography (FET-PET) imaging characteristics of adult brainstem glioma (BSG).Materials and methodsFET-PET imaging and progression-free survival (PFS) of 16 adult patients with BSG was analyzed (9 high-grade gliomas, 7 low-grade gliomas). SUVmax, TBR, and time activity curves of FET-PET were calculated.ResultsProgressive gliomas had higher SUVmax (3.57 ± 1.47 vs. 1.60 ± 0.51; p = 0.003) and TBRmax (3.00 ± 1.12 vs. 1.36 ± 0.33; p = 0.001) than stable gliomas. Kaplan-Meier analysis showed longer PFS of tumors with TBRmax < 2.0 compared to tumors with TBRmax > 2.0 (665 ± 32 days versus 220 ± 39 days; p < 0.001).ConclusionFET-PET uptake might be associated with disease progression in adult BSG.



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