CASP8, XRCC1, WRN, NF2 and BRIP1 polymorphisms analysis reveals their genetic susceptibility for meningioma risk and the association with tumor-related phenotype in Chinese population.

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CASP8, XRCC1, WRN, NF2 and BRIP1 polymorphisms analysis reveals their genetic susceptibility for meningioma risk and the association with tumor-related phenotype in Chinese population.

World Neurosurg. 2018 Mar 23;:

Authors: Huang G, Feng J, Hao S, Li D, Wang K, Wang L, Wu Z, Wan H, Zhang L, Zhang J

Abstract
OBJECTIVE: To investigate 10 candidate SNPs in five genes (CASP8, XRCC1, WRN, NF2 and BRIP1) to confirm the association between the five genes and the meningioma risk in Chinese population.
METHODS: In the present study, we examined 10 candidate SNPs in five genes (CASP8, XRCC1, WRN, NF2 and BRIP1) to confirm the association between the five genes and the meningioma risk and tumor-related phenotype in 433 subjects, including 215 subjects with meningioma and 218 controls.
RESULTS: The polymorphisms rs4968451T>G in BRIP1 were significantly associated with the risk of meningioma (TT vs. TG vs. GG additive P=0.005; TT+TG vs. GG dominant P= 0.015; TT/GT+GG Recessive p=0.034). And the significant association was only found in females for BRIP1 rs4968451T>G (TT+TG vs. GG dominant P= 0.001; TT/GT+GG Recessive p=0.044). We observed no significant association between genotypes and the meningioma risk for the other nine SNPs. Throughout genotype-phenotype analysis, that the genotype of BRIP1 rs4968451T>G were also strongly associated with tumor-related phenotypes, including the tumor grade and tumor subtypes. BRIP1 rs4968451T>G was associated with markedly grade I meningioma risk (TT+TG vs. GG dominant P= 0.008; TT/GT+GG Recessive p=0.020). Additionally, BRIP1 rs4968451T>G was associated with markedly meningothelial and transitional meningioma risk. Furthermore, the genotype of CAPS8, XRCC1 and NF2 was associated with different subtype of meningioma risk, respectively.
CONCLUSIONS: These study indicated a role for BRIP1 gene variations in meningioma and may be informative for future genetic or biological studies on meningioma .These findings will assist in further understanding the genetic causation for meningiomas and guide more effective biological interventions to facilitate meningiomas.

PMID: 29581016 [PubMed - as supplied by publisher]

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