CD36 modulates fasting and preabsorptive hormone and bile acid levels.

CD36 modulates fasting and preabsorptive hormone and bile acid levels.

J Clin Endocrinol Metab. 2018 Mar 12;:

Authors: Shibao CA, Celedonio JE, Tamboli R, Sidani R, Love-Gregory L, Pietka T, Xiong Y, Wei Y, Abumrad NN, Abumrad NA, Flynn CR

Abstract
Context: Abnormal fatty acid (FA) metabolism contributes to diabetes and cardiovascular disease. The FA receptor CD36 has been linked to risk of metabolic syndrome. In rodents CD36 regulates various aspects of fat metabolism but whether it has similar actions in humans is unknown. We examined impact of a coding single-nucleotide polymorphism in CD36 on post-prandial hormone and bile acid (BA) responses.
Objective: To examine if the minor allele (G) of coding CD36 variant rs3211938 (G/T) which reduces CD36 level by approximately 50% influences hormonal responses to a high-fat meal (HFM).
Design: Obese African American (AA) women carriers of the G allele of rs3211938 (G/T) and weight-matched noncarriers (T/T) were studied before and after a HFM.
Setting: Two-center study.
Participants: Obese AA women.
Intervention: High-fat meal.
Main Outcome Measures: Early preabsorptive responses (10 min) and extended excursions in plasma hormones (c-peptide, insulin, incretins, ghrelin, FGF19, FGF21), BAs and serum lipoproteins (chylomicrons, VLDL) were determined.
Results: At fasting, G allele carriers had significantly reduced cholesterol and glycodeoxycholic acid and consistent but nonsignificant reductions of serum lipoproteins. Levels of GLP-1 and pancreatic polypeptide (PP) were reduced 60-70% and those of total BAs were 1.8 fold higher. After the meal, G allele carriers displayed attenuated early (-10 to 10 min) responses in insulin, c-peptide, GLP-1, GIP and PP. BAs exhibited divergent trends in G-allele carriers versus noncarriers concomitant with differential FGF19 responses.
Conclusions: CD36 plays an important role in the preabsorptive hormone and BA responses that coordinate brain and gut regulation of energy metabolism.

PMID: 29546316 [PubMed - as supplied by publisher]

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